| Date | Location | Result | |
| 03/04/22 | Bo Ryan Court, Platteville, Wis. | Calvin University 77, Saint John's Univ. 71 | Box score |
| 02/27/22 | Sexton Arena, Collegeville, Minn. | Saint John's Univ. 75, Macalester College 71 | Box score |
| 02/25/22 | Claire Lynch Hall, St. Joseph, Minn. | Saint John's Univ. 76, St. Olaf College 57 | Box score |
| 02/23/22 | Sexton Arena, Collegeville, Minn. | Saint John's Univ. 74, Hamline University 53 | Box score |
| 02/16/22 | Sexton Arena, Collegeville, Minn. | Saint John's Univ. 87, Gustavus Adolphus 65 | Box score |
| 02/12/22 | Si Melby Hall, Minneapolis, Minn. | Saint John's Univ. 68, Augsburg University 65 | Box score |
| 02/09/22 | Skoglund Center, Northfield, Minn. | St. Olaf College 77, Saint John's Univ. 70 | Box score |
| 02/07/22 | Sexton Arena, Collegeville, Minn. | Saint John's Univ. 65, Hamline University 35 | Box score |
| 02/05/22 | Sexton Arena, Collegeville, Minn. | Saint John's Univ. 59, Macalester College 45 | Box score |
| 02/02/22 | Sexton Arena, Collegeville, Minn. | Saint John's Univ. 72, Bethel University 51 | Box score |
| 01/29/22 | Memorial Auditorium, Moorhead, Minn. | Saint John's Univ. 80, Concordia-Moorhead 65 | Box score |
| 01/26/22 | West Gymnasium, Northfield, Minn. | Saint John's Univ. 65, Carleton College 50 | Box score |
| 01/22/22 | Sexton Arena, Collegeville, Minn. | Saint John's Univ. 83, St. Scholastica 62 | Box score |
| 01/19/22 | Sexton Arena, Collegeville, Minn. | Saint John's Univ. 80, Saint Mary's Univ. 53 | Box score |
| 01/15/22 | Sexton Arena, Collegeville, Minn. | Augsburg University 67, Saint John's Univ. 66 | Box score |
| 01/12/22 | Gus Young Court, St. Peter, Minn. | Saint John's Univ. 69, Gustavus Adolphus 55 | Box score |
| 01/10/22 | Sexton Arena, Collegeville, Minn. | Saint John's Univ. 75, St. Olaf College 72 | Box score |
| 12/14/21 | Sexton Arena, Collegeville, Minn. | Saint John's Univ. 80, Carleton College 51 | Box score |
| 12/11/21 | Leonard Center, St. Paul, Minn. | Saint John's Univ. 85, Macalester College 62 | Box score |
| 12/08/21 | Hutton Arena, St. Paul, Minn. | Saint John's Univ. 69, Hamline University 61 | Box score |
| 12/04/21 | Sexton Arena, Collegeville, Minn. | Saint John's Univ. 87, Concordia-Moorhead 76 | Box score |
| 12/01/21 | SMU Gym, Winona, Minn. | Saint John's Univ. 73, Saint Mary's Univ. 63 | Box score |
| 11/24/21 | Siebens Fieldhouse Gym, Storm Lake, Iowa | Saint John's Univ. 81, Buena Vista Univ. 65 | Box score |
| 11/20/21 | Reif Gym, Duluth, Minn. | Saint John's Univ. 74, St. Scholastica 51 | Box score |
| 11/13/21 | Shirk Center, Bloomington, Ill. | Hope College 62, Saint John's Univ. 58 | Box score |
| 11/12/21 | Shirk Center, Bloomington, Ill. | UW-Oshkosh 89, Saint John's Univ. 55 | Box score |
| 11/06/21 | Mertz Mortorelli Gym, Superior, Wis. | Saint John's Univ. 67, UW-Superior 45 | Box score |
| 11/05/21 | Mertz Mortorelli Gym, Superior, Wis. | Saint John's Univ. 85, UW-River Falls 67 | Box score |